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KMID : 0894520000040020137
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Development & Reproduction
2000 Volume.4 No. 2 p.137 ~ p.145
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Formation and Differentiation of Human Fetal Ovarian Follicles
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도병록
이창주/송강원/윤현수/노성일/윤용달
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Abstract
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The regulatory mechanisms of the initiation and the formation of ovarian follicles during fetal stage of mammals are largely unknown. In addition to the gonadotropins secreted from pituitary, various growth factors, and steroid hormones are believed to be involved in the differentiation and initiation of growth of primordial follicles consisting of primordial germ cells migrated from yolk sac and streamed cells from mesonephric somatic cells. In human, primordial follicles that have already initiated differentiation at fetal stage undergo either folliculogenesis to ovulate or atresia after growth. Some of primordial follicles remain without growth for 50 years or longer. The objective of this paper is to review the mechanism of the formation, growth arrest, and initiation of primordial follicles in human fetal and neonatal ovaries.
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KEYWORD
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